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Carbohydrate Nanotechnology: Hierarchical Assemblies and Information Processing with Oligosaccharide-Synthetic Lectin Host-Guest Systems
Technical Report,01 Apr 2011,28 Feb 2013
NEW YORK UNIV NY NEW YORK United States
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Carbohydrates are used throughout nature to direct information processing and hierarchical assembly, but are rarely explored in the context of synthetic nanotechnology. Carbohydrates were explored as targets for synthetic receptors, in nanopatterning, and for directing the movement of nanoswimmers. A synthetic carbohydrate receptor that achieves the highest reported selectivity for mannosides over other pyranosides 281 via a unique cooperative binding mechanism has been developed. At high temperatures, a 21 receptor mannoside complex forms, and at low temperatures, a 12 receptor mannoside complex forms. The structures and thermodynamic binding properties of these complexes have been characterized by nuclear magnetic resonance spectroscopy and molecular modeling. Additionally, Polymer Pen Lithography has been combined with the copper catalyzed azide-alkyne click reaction and the Staudinger Ligation, two bioorthogonal organic reactions, to create functional carbohydrate arrays. This patterning approach controls the position, orientation, and feature diameter of the deposited molecules to create sub-1 micrometer features of carbohydrates across centimeter-scale areas. Finally, a new mathematical model that describes the flipping, turning, and dispersion of gold-platinum catalytic nanomotors has been derived that explains their diffusion over long times and accounts for the imperfections on the nanorod structures that inevitably arise during any manufacturing process.
APPROVED FOR PUBLIC RELEASE