Accession Number:

AD1013100

Title:

Functional and Celluar Assessment of Limited Remyelination in the Cuprizone Model

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

• Hibbits,Norah E.

Report Date:

2012-01-01

Pagination or Media Count:

126.0

Abstract:

The promotion of remyelination after chronic or prolonged episodes of demyelination is an important therapeutic goal for demyelinating diseases. The leading cause of demyelination in humans is multiple sclerosis MS. This thesis work focused on a mouse model of MS to examine cellular and molecular mechanisms that may cause limited remyelination after chronic demyelination. Cuprizone, a neurotoxicant, was used to induce experimental demyelination. This model mimics the effects of acute and chronic time courses of demyelinating disease progression.

Descriptors:

• demyelinating diseases
• nervous system
• models
• central nervous system
• therapeutics

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE