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Accession Number:
AD1013086
Title:
The Effect of Diazoxide and Dimethyl Sulfoxide on Behavioral Outcomes and Markers of Pathology Following Controlled Cortical Impact
Descriptive Note:
Technical Report
Corporate Author:
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD BETHESDA United States
Report Date:
2012-07-16
Pagination or Media Count:
241.0
Abstract:
Traumatic brain injury TBI is a significant worldwide problem with an estimated incidence of at least 200 cases per 100,000 people per year. Due to recent military conflicts in the Middle East, a tremendous spike in the incidence of combat related brain injury has occurred over the past decade. Over the last 30 years, preclinical research focused on evaluating potential pharmacologic therapeutic agents has produced multiple promising candidates however, to date no single drug intervention has consistently shown benefit when administered in the clinical setting. Fortunately, new potential therapeutic targets are being identified at a staggering rate as technology advances and our understanding of the pathology behind brain injury improves. In an effort to advance the therapeutic and molecular target realms of basic research, our team tested two hypotheses. First, that diazoxide DZ, a putative mitochondrial KArP opener, administered after brain injury will result in short and long-term improvement in memory, motor, and behavioral function and second, that moderate and severe traumatic brain injury will result in early and sustained widespread alterations of polysialylated neural cell adhesion molecule PSA-NCAM expression.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
