Accession Number:

AD1013067

Title:

GABAA Receptor-Mediated Activity in a Model of Cortical Dysplasia

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

Report Date:

2012-06-29

Pagination or Media Count:

222.0

Abstract:

Cortical dysplasia is a developmental abnormality characterized by changes in the structure and function of the neocortex. This disorder is implicated in many neuropsychiatric disorders such as epilepsy, autism and schizophrenia, and results from failure of immature neurons to appropriately migrate to their cortical targets. We developed a model of cortical dysplasia by administering methylazoxy methanol MAM, an anti-mitotic, to pregnant ferrets on gestational day 33 leading to abnormal cortical layering, increased expression of GABAA receptors GABAAR and altered distribution of neurons derived from the ganglionic eminence GE.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE