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Host Cell Virus Entry Mediated by Australian Bat Lyssavirus Envelope G glycoprotein

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Australian bat lyssavirus ABLV is a recently emerged rhabdovirus of the genuslyssavirus considered endemic in Australian bat populations that causes a neurological disease in people indistinguishable from clinical rabies. There are two distinct variants of ABLV, one that circulates in frugivorous bats genus Pteropus and the other in insectivorous microbats genus Saccolaimus. Three fatal human cases of ABLV infection have been reported, the most recent in 2013, and each manifested as acuteencephalitis but with variable incubation periods. Importantly, two equine cases also arose recently in 2013 the first occurrence of ABLV in a species other than bats or humans. ABLV infects host cells through receptor-mediated endocytosis and subsequent pH-dependent fusion facilitated by its single fusogenic envelope glycoprotein G, but the specific host factors and pathways involved in ABLV entry have not been determined.

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