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Mechanisms of Ionizing Radiation-Induced Cell Death in Primary Lung Cells

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Exposure to high doses of ionizing radiation IR causes serious biological damage that can lead to death. During the course of radiotherapy, the use of IR for the treatment of thoracic cancers is limited by IR-induced cell death to the underlying normal lung tissue potentially leading to pneumonitis andor fibrotic remodeling of the lung. Studies on the mechanisms of IR-induced cell death have been exponentially increasing, however, most of these studies are conducted on immortalized cancer cell lines that are not lung-derived and therefore do not represent the biological status of normal lung cells. We investigated the mechanisms of IR-induced cell death in low passage cultures of primary pulmonary artery endothelial cells PAEC exposed to varying doses of X-rays. We observed that irradiated PAEC undergo accelerated senescence as the primary mode of cell death at doses examined.

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