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Identification of the GnRH-(1-5) Receptor and Signaling Pathway
Uniformed Services University Of The Health Sciences Bethesda United States
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The decapeptide gonadotropin-releasing hormone GnRH is a central regulator of pubertal onset and reproductive function. In mammals, GnRH is released into the medianeminence of the hypothalamus to stimulate the pituitary release of the gonadotropins. Inturn, these hormones regulate the gonadal production of steroid hormones, which act as feedback modulators of the GnRH neuroendocrine system. Developmental defects in this regulation can lead to hypogonadotropic hypogonadism where the onset of puberty and fertility are impaired. Such is the case in patients suffering from Kallmann Syndrome KS where GnRH neurons emanating from the olfactory placode during development do not reach their destination within the central nervous system. Despite ongoing research in this field, a complete molecular understanding in the development of KS remains elusive.
APPROVED FOR PUBLIC RELEASE