The Regenerative Response of Endogenous Neural Stem/Progenitor Cells to Traumatic Brain Injury
Uniformed Services University Of The Health Sciences Bethesda United States
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The complex pathological mechanisms following traumatic brain injury TBI limit repair of damaged tissue. Cell signaling molecules have the potential to create a supportive environment for regeneration after injury. and promote the regenerative response from endogenous cells. Sonic hedgehog Shh has been shown to maintain neural stem cells NSCs and promote oligodendrogenesis. This study examines the influence of Shh signaling on neuronal DCX or oligodendroglial NG2 progenitor responses, in either gray GM or white matter WM TBI models. A WM injury model in C57BL6J mice was characterized at the coronal level of the subventricular zone SVZ to compare the response of Shh-responsive-NSCs following WM and GM injury. Analysis during the first week post-injury showed a axon damage, neuroinflammation, demyelination. and redundant myelin figures in the corpus callosum CC, b an increase in NG2 cell proliferation in the SVZ and CC, and c an increase in JG2 cells in the CC.