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Pathological and Pathophysiological Alterations in Temporal Lobe Structures After Mild Traumatic Brain Injury

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Mild traumatic brain injury mTBI accounts for 80 percent of all head trauma cases annually. Patients that suffer from mTBI present with an array of physical, cognitive and emotional symptoms e.g., headache, disorientation, confusion, irritability known as post concussive syndrome PCS, which resolves fairly quickly after injury. Nonetheless, victims of mTBI are at risk of developing long-lasting cognitive and neuropsychiatric disorders, including memory deficits and anxiety. The absence of clear damage to the brain that can explain both the symptoms observed in PCS and the development of anxiety and cognitive disorders represents a challenge in the field of mTBI. The objective of this dissertation was to investigate the molecular, functional, and morphological alterations that contribute to the development of cognitive impairments and anxiety disorders following mTBI. We used the controlled cortical impact CCI model of traumatic brain injury TBI to induce mTBI in rats and investigated the pathophysiological alterations to the hippocampus and amygdala, as these two brain regions play a major role in the development of cognitive impairment and anxiety disorders, respectively.

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