Accession Number:

AD1012605

Title:

Comparison of Hydroxocobalamin Versus Norepinephrine Versus Saline in a Swine Model of Severe Septic Shock

Descriptive Note:

Conference Paper

Corporate Author:

59th Medical Wing Lackland AFB United States

Report Date:

2016-05-18

Pagination or Media Count:

6.0

Abstract:

Sepsis is associated with a mortality of nearly 30. Mortality is due, in part, to an uncontrolled inflammatory response. Matrix metalloproteinase-9 MMP-9 and heat shock protein 70 HSP 70 have been suggested to be biomarkers of severe sepsis and may be useful indicators of treatment success. Hydroxocobalamin HOC, which regulates inducible nitric oxide synthase and increases systemic vascular resistance, may be effective in treating sepsis-induced hypotension and reversing overexpression of inducible nitric oxide synthase. Objective To compare efficacy of HOC versus norepinephrine NOR versus saline in swine with lipopolysaccharide LPS-induced endotoxemia.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE