Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse
Technical Report,01 Jul 2015,30 Jun 2016
Virginia Commonwealth University Richmond United States
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Studies relating to the role autophagy in tumor dormancy revealed that transient inhibition of autophagy during ADR treatment resulted in prolonging tumor dormancy. However, complete knockdown of autophagy gene expedited tumor relapse. We also identified two distinct types of ADRinduced tumor dormancy including Ki67 low indolent and Ki67 quiescent tumor dormancy. Whereas that former was sensitive to immunoediting, escape and relapse, the latter was found to be resistant to tumor immunoediting and escape. Adoptive immunotherapy AIT was also found to support regression of ADRinduced dormant tumor cells.