The Molecular Epidemiology of Malaria in Western Kenya
Uniformed Services University Of The Health Sciences Bethesda United States
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Malaria epidemiology reflects a complex web of inter-related factors host, parasite, vector and environment. The nature, duration and severity of malaria infection depend upon these fixed and changing factors, and are complicated by varying levels of acquired immunity in individuals. The present research used molecular biology tools to examine three distinct topics related to malaria epidemiology 1 the distribution of TNF-alpha, IFN-gamma,IL-6, TGF-beta, and IL-10 gene polymorphisms 2 the rate and pattern of mixed Plasmodium species infections and 3 Plasmodium falciparum growth dynamics. The first two research topics were examined in a cohort of 248 males recruited from three highly endemic villages in western Kenya where severe malaria anemia is common. The third topic was investigated among 22 volunteers during the post-challenge phase of a malaria vaccine trial sponsored by Walter Reed Army Institute of Research.