Accession Number:

AD1012413

Title:

Affective Measures of Anger and Hostility and Brachial Artery Endothelial Function during Mental Stress and Forearm Occlusion

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

Report Date:

2001-06-06

Pagination or Media Count:

45.0

Abstract:

Mental stress triggers myocardial ischemia in patients with coronary artery disease, and may involve impaired functioning. of the endothelial lining of coronary blood vessels. The present study examined the effects of hostility and mental stress on flow-mediated brachial artery dilation using 20 echocardiography in II men and 17 women. Brachial artery diameter was measured before and after 4 minutes of forearm arterial occlusion by pneumatic cuff, mental stress induced by a public speaking task or mental arithmetic with harassment. a mental stress task combined with forearm occlusion, and administration of sublingual nitroglycerin. Brachial artery diameter increased significantly during all interventions. Brachial artery vasodilation during occlusion plus mental stress was significantly reduced in participants with high Hostile Affect. Vasodilation during the combined condition was similarly associated with Anger Hostility. Affective measures of anger and hostility were associated with impaired endothelial responses to hyperemia and mental stress.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE