The Role of Sex and Strain in Behavioral and Biologic Stress Responses of Rats
Uniformed Services University Of The Health Sciences Bethesda United States
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Stress has been implicated in the etiology of many behavioral disorders Le., drug abuse, feeding disorders and disease states i.e., hypertension, diabetes, depression. Individuals differ, however, in vulnerability to stress related disease. The goal of this doctoral research was to identify potential behavioral and possibly biochemical markers of stress vulnerability vs. resilience in male and female rats of two strains Sprague-Dawley and Long-Evans that might predict eventual development of specific stress-related behavioral disorders or diseases in certain subgroups of humans. The experiment assessed the effects of mild, repeated daily stress on multiple behaviors and biochemical indices within the same subjects to construct a detailed model of potential markers of stress vulnerability vs. resilience.