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Defining Tumor Cell and Immune Cell Behavior in Vivo during Pulmonary Metastasis of Breast Cancer

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Technical Report,01 Sep 2013,31 Aug 2014

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University of California, San Francisco San Francisco United States

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Metastasis is mediated by a complex set of factors, few of which are well understood. While a number of studies over the past several decades have linked function of the immune response to various outcomes in pulmonary metastasis it is currently poorly understood as to how immune cells engage with tumor cells to modulate metastatic success. In this period we have applied an advanced method of live microscopy of mouse lungs to define the earliest hours of lung metastasis. We have identified a novel behavior of tumor cells during the earliest hours of metastasis whereby the generate and release large numbers of blebs which we term microparticles. Importantly, we have initial data to suggest that these microparticles are encountered and ingested by cells of the local immune response theoutcome of which is still to be determined.

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