Nicotine-Induced Antinociception in Male and Female Sprague-Dawley Rats
Uniformed Services University Of The Health Sciences Bethesda United States
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Nicotine is a key pharmacologically-active ingredient in tobacco that has cognitive and behavioral effects, including antinociception. The present research examined effects of nicotine as an anti-nociceptive agent in male and female Sprague-Dawley rats. Nicotine was administered subcutaneously SC to 145 male and female Sprague-Dawley rats. Behavioral measures of nociception included tail-flick, hot-plate, and cold-flick. The Formalin test, a model for persistent pain, was used to examine nicotine-induced antinociception. After antinociceptive testing, animals were sacrificed and blood was collected and assayed for plasma 17-3-estradiol in females. testosterone in males, plasma nicotine and cotinine brain and spinal cord nicotine and cotinine levels.