Accession Number:

AD1012097

Title:

Nicotine-Induced Antinociception in Male and Female Sprague-Dawley Rats

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

Report Date:

1999-07-21

Pagination or Media Count:

183.0

Abstract:

Nicotine is a key pharmacologically-active ingredient in tobacco that has cognitive and behavioral effects, including antinociception. The present research examined effects of nicotine as an anti-nociceptive agent in male and female Sprague-Dawley rats. Nicotine was administered subcutaneously SC to 145 male and female Sprague-Dawley rats. Behavioral measures of nociception included tail-flick, hot-plate, and cold-flick. The Formalin test, a model for persistent pain, was used to examine nicotine-induced antinociception. After antinociceptive testing, animals were sacrificed and blood was collected and assayed for plasma 17-3-estradiol in females. testosterone in males, plasma nicotine and cotinine brain and spinal cord nicotine and cotinine levels.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE