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Low Volume Resuscitation with Cell Impermeants
Technical Report,30 Sep 2012,01 Jan 2016
Virginia Commonwealth University Richmond United States
Pagination or Media Count:
Shock induces loss of energy dependent volume control mechanisms, which cause cell and tissue swelling, compression of capillaries, and impairment of microcirculatory O2 transfer. The objective of the study was to increase the tolerance to the low volume state by passively moving water from the cell back into the microcirculation by loading patients with specialized cell impermeant agents. This decompresses and reloads the capillaries, and increases the efficiency of low volume oxygen transfer. Rats or Pigs were hemorrhaged in lactate controlled models and given various impermeant based low volume resuscitated LVR solutions. Outcomes were determined by cardiovascular, metabolic, and tolerance endpoints.
APPROVED FOR PUBLIC RELEASE