Accession Number:

AD1011465

Title:

Mechanisms of Synaptic Alterations in a Neuroinflammation Model of Autism

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author:

University of Nebraska Medical Center Omaha United States

Personal Author(s):

Report Date:

2015-10-01

Pagination or Media Count:

18.0

Abstract:

Here we investigated how Maternal Immune Activation MIA, a risk factor for autism spectrum disorders ASD affects the development of synapses. The central hypothesis is that altered expression of cytokines and chemokines in the brain results in impaired synaptic development and altered behavior. We employed the MIA mouse model and so far found that in offspring there is a reduction in the number of synaptic structures in vivo as well as reduced motility. Behavioral impairments relevant to ASD are also reported.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE