Characterization of the Virus and Monoclonal Antibody Binding Sites of the Mouse Hepatitis Virus Receptor
Uniformed Services University Of The Health Sciences Bethesda United States
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The attachment of Mouse Hepatitis Virus MHV, a coronavirus, to its cellular receptor on the host cell membrane is the first step leading to viral infection. The best characterized receptor for MHV is a 120 kDa glycoprotein encoded by the biliary glycoprotein Bgp la gene. Other murine Bgp glycoproteins also serve as receptors for MHV but with less efficiency. Bgps belong to the carcinoembryonic antigen family which, in turn, belongs to the immunoglobulin superfamily. Chimeric glycoproteinsand recombinant mutated receptor proteins were generated to identify the sites on the receptor that binds to the Mouse Hepatitis Virus strain AS9 MHV-AS9.