Accession Number:
AD1011221
Title:
Injury, inflammation and the emergence of human specific genes
Descriptive Note:
Journal Article
Corporate Author:
University of California San Diego School of Medicine, La Jolla San Diego United States
Personal Author(s):
Report Date:
2016-07-12
Pagination or Media Count:
5.0
Abstract:
In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.