Accession Number:

AD1011221

Title:

Injury, inflammation and the emergence of human specific genes

Descriptive Note:

Journal Article

Corporate Author:

University of California San Diego School of Medicine, La Jolla San Diego United States

Personal Author(s):

• Baird,Andrew
• Constantini,Todd
• Coimbra,Raul
• Eliceiri,Brian P

Report Date:

2016-07-12

Pagination or Media Count:

5.0

Abstract:

In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.

Descriptors:

• inflammation
• gene expression
• wounds and injuries
• models
• infection
• leukocytes
• human behavior
• human genome

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE