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Regulation of Pituitary Beta Endorphin Release: Role of Serotonin Neurons

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Beta-Endorphin-like immunoreactivity B-END-LI is present In highest concentration in the anterior AL and intermediate lobe IL of the pituitary gland from where it is released in response to pain and other stimuli. Several lines of evidence suggest that serotonin neurons influence nociception via mechanisms which involve opiate receptors and the release of endogenous opiate peptides within the central nervous system CNS and possibly from the pituitary. The purpose of the presentresearch was to determine whether serotonin neurons are involved in the regulation of pituitary B-END-LI secretion and therefore provide evidence for a functional relationship between serotonergic-stimulated release of pituitary B-END-LI and endogenous mechanisms of analgesia. Since the pituitary is the major source for blood-borne B-END-LI, the effects of serotonergic drugs on plasma levels of B-END-LI was used to study serotonergic control over pituitary 3-endorphin.

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