Toxicology Study No. S.0024589d 15, Human Cell Line Activation Test of the Novel Energetic, 3,4 -Dinitropyrazole (DNP)
Technical Report,01 Mar 2016,30 Apr 2016
Army Public Health Center (Provisional) Aberdeen Proving Ground United States
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The novel energetic 3,4-dinitropyrazole DNP is under consideration as a replacement for trinitrotoluene TNT in explosive formulations. The toxicological properties of DNP are under evaluation as part of this effort. This study assessed the skin sensitization potential of DNP through the human cell line activation test h-CLAT, an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the elicitation of a skin allergy. 3,4-DNP was found to be a sensitizer.