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Prospective Molecular Characterization of Burn Wound Colonization: Novel Tools and Analysis

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Technical Report,23 Sep 2011,22 Sep 2012

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Translational Genomics Research Institute Phoenix United States

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Microbial colonization is thought to play a critical role in the healing trajectory of wounds. The microbial load and community composition are both important variables that, historically, were extremely difficult to characterize. Under this award, we have developed a suite of cutting-edge molecular tools, databases, and analytical approaches to enable more accurate characterization of wound microbiota. In the past year, we developed and validated culture-independent molecular tools for quantifying and identifying wound fungi. We also initiated a prospective study to elucidate the impact of hyperbaric oxygen therapy HBOT on chronic wound microbiota, using our novel tools and approaches. We have also begun using whole genome sequence analysis to identify the genetic characteristics that enable Staphylococcus aureus to progress from simple skin and soft tissue infections to sepsis and endocarditis. We are confident that this work will lead to significant advancements in wound care and healing and human microbiome research in general.

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