APOL1 Oligomerization as the Key Mediator of Kidney Disease in African Americans
Technical Report,30 Sep 2014,29 Sep 2015
Beth Israel Deaconess Medical Center Boston, United States
Pagination or Media Count:
The work we are conducting is aimed at understanding, and eventually preventing and treating, kidney disease, in particular the APOL1-associated form of kidney disease that accounts for the high rate of kidney disease in African Americans. This work is based on the hypothesize that APOL1 kidney disease in African Americans results from abnormal aggregation of the APOL1 risk variant protein in anamyloid-like process. We are testing this hypothesis in in vitro systems, cells, model organisms, and human kidney biopsy specimens using molecular biology, biochemistry, protein chemistry, and microscopy-based approaches.