Accession Number:

AD1009876

Title:

APOL1 Oligomerization as the Key Mediator of Kidney Disease in African Americans

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author:

Beth Israel Deaconess Medical Center Boston, United States

Personal Author(s):

Report Date:

2015-10-01

Pagination or Media Count:

17.0

Abstract:

The work we are conducting is aimed at understanding, and eventually preventing and treating, kidney disease, in particular the APOL1-associated form of kidney disease that accounts for the high rate of kidney disease in African Americans. This work is based on the hypothesize that APOL1 kidney disease in African Americans results from abnormal aggregation of the APOL1 risk variant protein in anamyloid-like process. We are testing this hypothesis in in vitro systems, cells, model organisms, and human kidney biopsy specimens using molecular biology, biochemistry, protein chemistry, and microscopy-based approaches.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE