Combat-Related Heterotopic Ossification: Development of Animal Models for Identifying Mechanisms and Testing Therapeutics
Technical Report,15 Jun 2014,14 Jun 2015
The Geneva Foundation Lakewood United States
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HO is occurring at significantly higher frequencies in the current war-wounded population than in civilian populations and it is a common and significant problematic clinical entity for war-wounded patients. The available body of evidence suggests that polytraumatic blast injuries induce HO with high frequency as a result of a combination of systemic and local factors. Prevention of HO through the development of prophylactic treatments would reduce military treatment costs and the pain and suffering of Wounded Warriors. A critical hurdlein our investigation of HO etiology, treatment, and prevention is the absence of a reliable and reproducible small animal model that can be used to characterize combatrelated HO development, identify new prophylactictherapeutic targets, and test new HO countermeasures.