Accession Number:

AD1009578

Title:

Engineered Joint Lubrication for OA Prevention and Treatment

Descriptive Note:

Technical Report,15 Aug 2014,14 Aug 2015

Corporate Author:

JOHNS HOPKINS HOSPITAL BALTIMORE MD BALTIMORE United States

Personal Author(s):

Report Date:

2015-09-01

Pagination or Media Count:

22.0

Abstract:

1. Engineer a 1-step injection technology to modify the cartilage-fluid interface to reduce friction and ultimately joint degradation. We will leverage our new HA-binding peptide technology to functionalize normal and arthritic cartilage surfaces to localize and bind the synovial lubricant and biofunctional molecule HA, a current mainstay in clinical practice today to reduce pain and delay surgery. 2. Translate the HA-binding technology to preclinical joint models of post-traumatic osteoarthritis. The one-step injection of the HA-surface binding technology will be tested in a model of a common meniscal injury where osteoarthritis develops without treatment. The ability of the technology to reduce the progression, prevent, and treat osteoarthritis caused by joint destabilization will be determined.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE