Engineered Joint Lubrication for OA Prevention and Treatment
Technical Report,15 Aug 2014,14 Aug 2015
JOHNS HOPKINS HOSPITAL BALTIMORE MD BALTIMORE United States
Pagination or Media Count:
1. Engineer a 1-step injection technology to modify the cartilage-fluid interface to reduce friction and ultimately joint degradation. We will leverage our new HA-binding peptide technology to functionalize normal and arthritic cartilage surfaces to localize and bind the synovial lubricant and biofunctional molecule HA, a current mainstay in clinical practice today to reduce pain and delay surgery. 2. Translate the HA-binding technology to preclinical joint models of post-traumatic osteoarthritis. The one-step injection of the HA-surface binding technology will be tested in a model of a common meniscal injury where osteoarthritis develops without treatment. The ability of the technology to reduce the progression, prevent, and treat osteoarthritis caused by joint destabilization will be determined.
- Medicine and Medical Research