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Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

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Technical Report

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Ho-Chunk Technical Solutions Winnebago United States

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Between 1954 and 1975, more than 12,000 men entering or in military service in the United States US served as medical research volunteers for the countrys biological and chemical warfare defense programs. With their consent, these servicemen served as human volunteers in exposure experiments to a wide variety of biological and chemical substances, medications, vaccines, or simulants. The purpose of these tests was to use volunteers to evaluate the effect of biological and chemical substances on humans in an effort to determine US vulnerability to attack. The three main programs under which this testing took place were Project White-coat, Project 112, and Project SHAD Shipboard Hazard and Defense. Several reviews of the health status of volunteers in these exposure experiments have been done the years following the original studies and have found no conclusive evidence that receipt of investigational agents or substances was related to adverse health outcomes. None of the follow-up studies or reviews found differences in all-cause mortality between participants and controls, and none of the studies found consistent, clinically-significant groups of symptoms in those exposed. Despite these failures to determine that the tests had a long-term negative effect on the health of the men who participated in the exposures, many test participants continue to self-report their health as consistently lower than the health of non-participant controls. The purpose of this report is to provide documentation of potential long-term health effects of exposure to the agents, compounds and drugs tested. Literature searches and analyses of scientific and medical studies published between June 30, 2006 and December 1, 2015 have been reviewed for information concerning the potential long-term health effects of the volunteer human exposures. Evidence found in the literature for potential long-term health effects or sequelae does not necessarily mean that these symptoms have occurred

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