Investigation of Microcavitation-Induced Effects using in Vitro Models for Traumatic Brain Injury
Technical Report,01 Jan 2013,31 Dec 2015
University of Illinois at Chicago Chicago United States
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The project was focused on the development of in vitro biomimetic systems to examine the impact of microcavitation in the brain tissue. We have successfully designed and validated several biosystems to elucidate quantitatively potential biophysical and molecular mechanisms mediating bioeffects which arise from blast-induced shock waves and subsequently generated microbubbles i.e., microcavitation. The coupling mechanisms responsible for the bioeffects of microbubbles in brain tissues can now be better understood with detail, and lead to formulation of strategies to reverse some of the observed adverse effects.