Identification of Prostate Cancer-Specific microDNAs
Technical Report,25 Nov 2013,24 Nov 2015
University of Mississippi Medical Center Jackson United States
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Emerging evidence has suggested that eukaryotic cells can express a special group of extrachromosomal circular DNAs eccDNAs, called microDNAs. Unlike previously reported eccDNAs, microDNAs are relatively small in length, map to unique DNA sequence, and arise from genes, mostly likely resulting from microdeletions. Since they are usually in a circular form, they are more resistant to exonuclease than linear DNAs and can be stably present in the cells or even possibly in the circulating system. Therefore, overall goal of this application is to determine whether prostate cancer cells express such microDNAs which can be used to serve as valuable biomarkers for prostate cancer diagnosis or prognosis.