Understanding the Delay in Onset of Pagets Disease of Bone
Technical Report,30 Sep 2013,29 Jun 2015
University of Connecticut Farmington United States
Pagination or Media Count:
One of the key questions in Pagets disease of bone PDB is the nature of the trigger for initiation of the disease. Inheritance of a predisposing mutation in the Sequestosome 1SQSTM1 gene and childhood infection with Measles virus are critical, but how this leads to initiation of the disease only after a significant period of time has passed, is unclear. Understanding the genetics underlying this disease process and how the predisposing mutation interacts with the measles virus genome is the goal of this proposal. We have developed a model to compare the gene sets from significantly regulated genes affected by the measles virus genome expression in the context of the SQSTM1 mutation in human osteoblasts and carried out RNA-seq analysis on this model.