Quantification of VX Nerve Agent in Various Food Matrices by Solid-Phase Extraction Ultra-Performance Liquid ChromatographyTime-of-Flight Mass Spectrometry
Technical Report,01 Oct 2014,01 Jun 2015
Army Edgewood Chemical Biological Center Aberdeen Proving Ground
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Liquid chromatographyelectrospray ionization mass spectrometry with positive-ion modes of operation were used for the trace-level determination of O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate VX in various food matrices. The mixed-mode cation exchange MCX sorbent and Quick, Easy, Cheap, Effective, Rugged, and Safe QuEChERS methods were used for extraction of VX from food samples. The extraction efficiencies obtained with use of the MCX cartridge and QuEChERS methods were compared, and the results revealed that both methods performed similarly. Various VX concentrations, ranging from 5 to 500 ngmL, were spiked into food samples. The linear range of quantitation for VX was 1 to 330 ngmL. The total percent recoveries and percent relative standard deviations for VX in various food samples are reported.