Preventing Ototoxic Synergy of Prior Noise Trauma During Aminoglycoside Therapy
Technical Report,01 Dec 2014,30 Nov 2015
Oregon Health and Science University Portland United States
Pagination or Media Count:
Exposure to loud sounds causes temporary or permanent threshold shifts in auditory perception, with reversible or irreversible cellular damage in the cochlea. Noise trauma, or loud sound exposure, is particularly associated with military environments, especially when sustaining blast injuries. These injuries are frequently treated with aminoglycoside antibiotics that have broad-spectrum bactericidal activity for treating or preventing life-threatening infections. However, aminoglycosides are also toxic to the cochlea, leading to hearing loss and further degradation from pre-injury status. The combination of both prior noise trauma and aminoglycoside treatment can degrade auditory function greater than simple summation of the two insults. We have found that prior sound exposure enhances cochlear uptake of aminoglycosides, providing a mechanistic basis for the observed ototoxic synergy due to noise trauma and subsequent aminoglycoside treatment.