Accession Number:

AD1008253

Title:

ETS Gene Fusions as Predictive Biomarkers of Resistance to Radiation Therapy for Prostate Cancer

Descriptive Note:

Technical Report,15 Jul 2010,14 Jul 2011

Corporate Author:

The University of Michigan Ann Arbor United States

Personal Author(s):

Report Date:

2011-08-01

Pagination or Media Count:

29.0

Abstract:

The research goals of this grant proposal are to 1 investigate the effect of ETS gene fusions on radiation phenotype in preclinical models of prostate cancer, 2 to explore the mechanism of interaction between ERG the predominant ETS gene fusion product and the DNA repair protein DNA-PK, and 3 to determine if ETS gene fusion status is a clinical biomarker ofradio resistance for prostate cancer. The training goals of this grant proposal included a series of regular meetings with mentors, research seminars, journal clubs, and workshops, all of which are intended to help Dr. Feng develop as a translational scientist. This grant proposal was approved as a five-year award the current annual report summarizesaccomplishments over the first year of the grant, from July 15, 2010 to July 15, 2011.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE