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ETS Gene Fusions as Predictive Biomarkers of Resistance to Radiation Therapy for Prostate Cancer

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Technical Report,15 Jul 2010,14 Jul 2011

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The University of Michigan Ann Arbor United States

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The research goals of this grant proposal are to 1 investigate the effect of ETS gene fusions on radiation phenotype in preclinical models of prostate cancer, 2 to explore the mechanism of interaction between ERG the predominant ETS gene fusion product and the DNA repair protein DNA-PK, and 3 to determine if ETS gene fusion status is a clinical biomarker ofradio resistance for prostate cancer. The training goals of this grant proposal included a series of regular meetings with mentors, research seminars, journal clubs, and workshops, all of which are intended to help Dr. Feng develop as a translational scientist. This grant proposal was approved as a five-year award the current annual report summarizesaccomplishments over the first year of the grant, from July 15, 2010 to July 15, 2011.

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