Obesity/Overweight in Persons with Early and Chronic SCI: A Randomized Multi-Center Controlled Lifestyle Intervention
Technical Report,14 Sep 2010,29 Sep 2011
University of Miami School of Medicine Miami United States
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The overarching study objective is to reduce health hazards from an overweightobese body habitus and co-morbid cardiometabolic disorders in people with SCI, and to improve their life quality. The study is a four-year multi-center randomized clinical trial RCT conducted at 2 SCI rehabilitation research centers and two Veterans Affairs Medical Centers. The study is modeled after the Diabetes Prevention Program DPP, an NIH-sponsored 27-center RCT that reported a sustained 7 body weight reduction in pre-diabetic individuals accompanied by a 58 decrease in progression to type-2 diabetes. The lifestyle intervention approach incorporating diet, exercise, and behavioral adjustments was more effective than pharmacotherapy, benefited both genders and persons of all races, and has lasted 10 years after initiation.