Accession Number:

AD1007984

Title:

Role of Grainyhead in Kidney Cancer

Descriptive Note:

Technical Report,30 Sep 2012,29 Sep 2014

Corporate Author:

West Virginia University Research Corporation Morgantown United States

Personal Author(s):

Report Date:

2014-12-01

Pagination or Media Count:

11.0

Abstract:

The epithelial-mesenchymal transition EMT plays an important role in the genesis of renal cell carcinomas RCC. Signaling through the Hepatocyte Growth Factor HGF Met pathway plays a particularly crucial role in this EMT. We have now found that the expression of Grainyhead-like-2 GRHL2 attenuates the HGF-Met pathway by suppressing the expression of Met target genes, including multiple matrix metalloproteases, The globally acting co-activator protein p300 interacted directly with GRHL2 protein, and GRHL2 inhibited activation of transcription through p300. This novel mechanism offers a unique opportunity to globally suppress pro-invasivepro-metastatic gene expression in RCC.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE