Role of Grainyhead in Kidney Cancer
Technical Report,30 Sep 2012,29 Sep 2014
West Virginia University Research Corporation Morgantown United States
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The epithelial-mesenchymal transition EMT plays an important role in the genesis of renal cell carcinomas RCC. Signaling through the Hepatocyte Growth Factor HGF Met pathway plays a particularly crucial role in this EMT. We have now found that the expression of Grainyhead-like-2 GRHL2 attenuates the HGF-Met pathway by suppressing the expression of Met target genes, including multiple matrix metalloproteases, The globally acting co-activator protein p300 interacted directly with GRHL2 protein, and GRHL2 inhibited activation of transcription through p300. This novel mechanism offers a unique opportunity to globally suppress pro-invasivepro-metastatic gene expression in RCC.