Opioid Abuse after TBI
Technical Report,01 Jul 2011,30 Jun 2015
University of Alabama at Birmingham Birmingham United States
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The goal of this project is to evaluate the hypothesis that traumatic brain injury TBI induces alterations in the brains reward circuitry which may make an injured brain more susceptible to the rewarding effects of opioids. We conducted experiments to evaluate the hypothesis that TBI causes changes in the analgesic response to opioids following acute and repeated drug administration. We secondly tested the hypothesis that moderate TBI increases the susceptibility for opioid abuse as measured by an alteration in the rewarding properties of oxycodone. We have completed the experimentation and found that TBI induces alteration induration of transient unconsciousness, the rewarding properties of oxycodone, and the brain circuitry related to reward signaling. We also found that TBI does not significantly change the analgesic properties of oxycodone or the rewarding effects of food. We conclude from our study that TBI induces alterations in the brain reward circuitry which lead to a significant increase in the rewarding effects of oxycodone.