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Objective Methods to Test Visual Dysfunction in the Presence of Cognitive Impairment

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Technical Report,15 Sep 2010,14 Sep 2015

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University of Iowa Iowa City United States

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To develop and validate objective tests to diagnose vision deficits in patients with cognitive impairment and ensure effective monitoring of their treatment. Objective methods to monitor visual function include 1 the pupil light reflex PLR, 2 light evoked potentials VEP from the brain and from the eye and 3 purposeful eye movements to track targets that are resolved. Three major objective tests of vision were successfully developed and optimized to detect disease. These were 1 the pupil light reflex either comparing the two eyes or independently evaluating each eye separately for retina or optic nerve damage, 2 eye movement based analysis of target acquisition, fixation, and eccentric viewing as a means of detecting central visual field damage and central nervous system disturbances i.e. multiple sclerosis, traumatic brain injury, dementia, and 3 wireless recording of evoked visual potentials for assessing regional damage to different locations of the visual field within a very short testing time under 60 seconds. Objective tests of vision will greatly improve eye care by providing faster, lower cost testing that can beperformed in remote settings and will provide a new tool for assessing innovative treatments being developed to save orrestore vision.

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