Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer
Technical Report,15 Sep 2014,14 Sep 2015
HEALTH RESEARCH, INC., BUFFALO United States
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The proposed studies are expected to 1 identify genetic variations in the genes of androgen transporters that are associated with the racial differences in prostate cancer aggressiveness 2 identify key androgen transporters of which the expression andor the alteration of expression in cancer relative to benign prostate tissue are associated with racial differences in prostate cancer aggressiveness. Progress in the reporting period includes 1 approval for IRB protocols that are needed for using DNA samples from the North Carolina-Louisiana Prostate Cancer Project PCaP, and for IHC and in situ RNA hybridization staining of a TMA set and tissue sections from Roswell Park Cancer Institute RPCI and PCaP, respectively 2 completion of DNA samples processing by PCaP for genotyping at RPCI 3 selection and ordering of probes of genetic variants for genotyping 4 optimization of the conditions for IHC and in situ RNA hybridization and 5 optimization of conditions for in vitro functional characterization of candidate transporters for androgen uptake.