Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse
Technical Report,15 Sep 2013,14 Sep 2015
William Marsh Rice University Houston United States
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The purpose of this work is to utilize monocytemacrophage-enabled delivery, a novel therapeutic delivery system that we pioneered, to increase the effectiveness and decrease thetoxicity of the treatment of intracranial metastases from primary breast cancer. Our objective in this proposal is to deliver therapeutics to brain metastases using a nanoshellNS-double-stranded DNA dsDNA-drug complex loaded within monocytesmacrophages. Once present within the metastasis, we aim to release the drug by transcranial irradiation atnear-infrared NIR wavelengths. Our studies have provided fundamental information on a number of aspects of the delivery of therapeutics by NSdsDNA.