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Development of an Injectable Salmon Fibrinogen-Thrombin Matrix to Enhance Healing of Compound Fractures of Extremities

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Technical Report,30 Sep 2009,31 Aug 2012

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Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Rockville United States

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Four treatments were compared in an acute femur fracture model in swine for their capacity to improve the progress of bone healing and regeneration. The treatments examined were 1 salmon fibrinogen and thrombin, 2 porcine fibrinogen and thrombin, 3 bovine collagen and a commercial FDA approved treatment called CopiOs. The treatments were instilled into the injury site and the bone was stabilized by surgical external fixation. The subject animals were maintained for 3 weeks and examined biweekly using fluoroscopy to visualize the bone healing and Near Infrared Spectroscopy, electric impedance measurement and Doppler ultrasound to assess the healing of the sound tissue. Wound severity was consistent in 29 animals. Cellularity and bone regeneration varied by treatment with CopiOS being the least effective in inducing a growth response and salmon fibrinogen and porcine fibrinogen being the most inductive. Computerized analysis of the CT and histology were consistent with human interpretation. A rat survival mode has been developed to permit longitudinal PETstudies.

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