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Clinical Characterization and Imaging of Triggered Attacks in Chronic Migraine and Posttraumatic Headache

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Technical Report,30 Sep 2014,20 Jun 2015

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University of Southern California Los Angeles United States

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Chronic posttraumatic headache PTH is a disabling disorder that affects millions of individuals worldwide. The Principal Investigators PIs of this application proposed to develop human models of PTH by characterizing clinical features and correlated changes in brain activity before and during triggered attacks. The PIs hypothesized that the different headache triggers nitroglycerin NTG and prostaglandin E2 PGE2 would produce different types of headache and would be associated with different patterns of brain metabolism that would reveal fundamental mechanisms of PTH. The studies were submitted for and achieved IRB approval at UCLA, and plans were in place to begin subject recruitment for the studies. However, because of administrative issues at UCSF Dr. Goadsbys move leading to a change to a part-time appointment there, and because of an unexpected inability to obtain pharmaceutical grade PGE2, the actual research studies were not initiated, and the study has now been terminated. We are in the process of establishing a collaboration between UCLA and Kings College London the location of Dr. Goadsbys new position and plan to move ahead with a similar but revised study once this formal collaboration is established. We will therefore continue to pursue the goals of this study in the future, but at this time the study is terminated.

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