Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)
Technical Report,30 Sep 2012,29 Sep 2015
University of Colorado, Boulder Boulder United States
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This 3 year multi-site project is now complete. It has successfully studied the role of toll like receptor 4 in both opioid and cocaine reward reinforcement. In addition it has successfully documented the potential of naltrexone a clinically relevant, blood brain barrier permeable, non-opioid toll like receptor 4antagonist as an inhibitor of the rewarding reinforcing effects of cocaine and opioids. Notably, it suppresses reinstatement to drug seeking relapsesupportive of the interest in this compound for aiding drug abusers in the goal of avoiding relapse. In exploring brain mechanisms underlying these effects, we have accrued evidence supportive of both nucleus accumbens and ventral tegmental nucleus involvement.