Investigation of LSM Proteins as Scaffolds in Bionanotechnology
University of Canterbury Christchurch New Zealand
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Self-assembling materials have gained attention in the field of nanotechnology due to their potential to be used as building blocks for fabricating complex nanoscale devices. The biological world is abundant with examples of functional self-assembling biomolecules. Proteins are one such example, found in a variety of geometries and shapes. This research is focused on the use of ring-shaped self-assembling proteins, called Lsm proteins, as componentary for applications in bionanotechnology. Lsm proteins were used because of their spontaneous association into stable rings, tolerance to mutations, and affinity to RNA. This thesis primarily focused on the thermophilic Lsm from Methanobacterium. thermoautotrophicum that assembles as heptameric rings.
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