The Effect of Age on the Susceptibility and Severity of Demyelination
Technical Report,01 Aug 2012,31 Jul 2015
McGuire Research I institute Richmond United States
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The premise of this proposal which utilized a mouse model of MS known as experimental allergic encephalomyelitis was two-fold first- that as animals age they become more susceptible to demyelinating disease and secondly that a molecule known to mediate the connection of myelin to the axonal membrane known as neurofascin was a key factor in determining the susceptibility of animals to demyelination. The research substantiated both of these premises although older animals came down with disease at a somewhat later time point than younger cohorts, they became significantly sicker at this later time point in addition when neurofascin was greatly decreased in a transgenic mouse the consequence was that these mice became sicker much quicker than a cohort of mice with normal levels of neurofascin. Therefore we have identified a key molecule related to susceptibility to demyelination neurofascin and showed that increasing age renders animals to a more profound disease state even though it occurs at a later time point.