Accession Number:

AD1007364

Title:

Breast Cancer Chemoresistance Mechanisms Through PI 3-Kinase and Akt Signaling

Descriptive Note:

Technical Report,01 May 2012,30 Apr 2015

Corporate Author:

Beth Israel Deaconess Medical Center Boston United States

Personal Author(s):

Report Date:

2015-07-01

Pagination or Media Count:

28.0

Abstract:

We have discovered that the Akt pathway modulates breast cancer cell survival in response to genotoxic agents, and discovered a new substrate of Akt,MERIT40, that is phosphorylated upon exposure of cells to chemotherapeutic drugs. We propose that this represents a major mechanism by which cells exposed to these drugs evade cell death by apoptosis and thus become resistant to the damaging effects of clinically-relevant chemotherapy agents. These findings have important ramifications for the use of chemotherapy drugs in breast cancer patients, and many also suggest that MERIT40 may be used as a clinically relevant biomarker for resistance to doxorubicin.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE