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Positioning Bascularized Composite Allotransplantation with the Spectrum of Transplantion

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Technical Report,15 Sep 2014,14 Sep 2015

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Duke University Durham United States

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This proposal utilizes a comprehensive approach to efficiently refine the transplantation of vascularized peripheral tissues e.g. hand, face into a useful therapeutic option for individuals in need of advance tissue reconstruction and replacement. The proposal addresses the needs of VCA, namely, a need for therapies that prevent rejection with limited impairment of the recipients protective immunity, and means of accurate monitoring and diagnosis of disorders such as rejection in a manner that will facilitate prompt, specific therapy. Studies include pre-clinical models with proven clinical relevance to assess the performance of clinically applicable therapies. Additionally, we will focus on the establishment of a VCA biorepository and the assessment of clinical material histologically to draw parallels between pre-clinical and clinical studies. We will use our established non-human primate model of VCA with proven clinical relevance to use human reagents so that data derived can be directly applied to the design of clinical protocols.

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