Accession Number:

AD1007344

Title:

Positioning Bascularized Composite Allotransplantation with the Spectrum of Transplantion

Descriptive Note:

Technical Report,15 Sep 2014,14 Sep 2015

Corporate Author:

Duke University Durham United States

Personal Author(s):

Report Date:

2015-10-01

Pagination or Media Count:

6.0

Abstract:

This proposal utilizes a comprehensive approach to efficiently refine the transplantation of vascularized peripheral tissues e.g. hand, face into a useful therapeutic option for individuals in need of advance tissue reconstruction and replacement. The proposal addresses the needs of VCA, namely, a need for therapies that prevent rejection with limited impairment of the recipients protective immunity, and means of accurate monitoring and diagnosis of disorders such as rejection in a manner that will facilitate prompt, specific therapy. Studies include pre-clinical models with proven clinical relevance to assess the performance of clinically applicable therapies. Additionally, we will focus on the establishment of a VCA biorepository and the assessment of clinical material histologically to draw parallels between pre-clinical and clinical studies. We will use our established non-human primate model of VCA with proven clinical relevance to use human reagents so that data derived can be directly applied to the design of clinical protocols.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE