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Molecular Profiling of Intraductal Carcinoma of the Prostate

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Technical Report,30 Sep 2014,29 Sep 2015

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Johns Hopkins University Baltimore United States

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Defined by the presence of malignant cells spreading within intact prostatic ducts and acini, intraductal carcinoma of the prostate IDC-P occurs almost exclusively in high Gleason grade and stage tumors and is a consistent independent risk factor for tumor progression and death. Importantly, however, IDC-P is currently systematically under-diagnosed in needle biopsies because it has significant morphologic overlap with another intraepithelial lesion, high grade prostatic intraepithelial neoplasia HGPIN. We hypothesize that IDC-P represents progression of invasive high-risk prostate carcinoma, and thus is molecularly distinct from HGPIN. Herein, we have begun to conduct an unbiased, three-pronged set of experiments to definitively identify the molecular signature of IDC-P using a combination of protein, RNA, and DNA-based assays. Aim 1 of the project has been completed following HRPO approval 5-22-15 and results were recently published. Currently, we are working to finish Aims 2 and 3.

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