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NFAT Signaling and the Tumorigenic Microenvironment of the Prostate

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Technical Report,30 Sep 2014,29 Sep 2015

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Washington University Saint Louis United States

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Although the importance of microenvironment in PCa is widely recognized, the molecular and cellular processes leading from genetic changes in the prostatic epithelium to the establishment of a tumorigenic microenvironment for PCa is unclear in most contexts. With our finding of NFATc1 being an oncogene and has a potential role in prostate cancer, we proposed to study two main areas divided into 3 specific aims. First, the detailed study of the tumorigenic microenvironment and the correlation between NFATc1 and PCa status in humans will help facilitate the development of clinically useful biomarkers for both diagnostic and prognostic purposes. Many of the factors we are targeting in the prostate cancer microenvironment are secreted factors that may be present in serum andorurine at measurable levels, making them suitable for the development of non-invasive clinical tests. Second, the illustration of the main cellular and molecular components in the tumorigenic microenvironment provides new druggable targets aimed at reversing the effects of the alterations in the microenvironment.

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