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Transgastric Local Pancreatic Hypothermia: A Novel, Rapid Multimodal Therapy for Acute Pancreatitis

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Technical Report,08 Jan 2015,07 Jan 2016

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Mayo Clinic Arizona Scottsdale United States

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Purpose Study if transgastric local hypothermia of the pancreas reduces the metabolic demand of the pancreas during acute pancreatitis AP and AP severity. Scope 1 Using metabolic imaging of the pancreas to predict its severity 2 Using transgastric cooling as a treatment modality for AP. These are proposed in Aim-3 of the grant. Time period of study Jan to Dec 2015 Major Findings 1 There is a significant increase in the uptake of Non-Radioactive Near Infra-Red 2-Deoxyglucose IRDye registered 800CW 2-DG in severe AP over controls which is detectable within an hour after AP induction without cooling. 2 Therapeutic transgastric hypothermia reduces severity in the GTL model of pancreatitis. Result 1 Poster presented at the American Pancreatic Association annual meeting November 2015 entitled In Vivo Imaging of Non-Radioactive Near Infra-Red 2-Deoxyglucose During Mild and Severe Acute Pancreatitis AP in Rats. 2 Manuscript reviewed at PLOS ONE, minor issues addressed. The title is Characterization and predictive value of near infrared 2-deoxyglucose optical imaging in severe acute pancreatitis. Here we note that In-vivo fluorescent imaging of IRDye registered 800CW 2-DG can predict the AP severity early during the disease better than conventional markers of severe AP. Significance Metabolic imaging of the pancreas can predict AP severity early in the disease. Ongoing studies The studies in the intraductal GTL model are almost complete. We shortly will start studying this in the taurocholate model of AP and complete the other studies proposed.

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