Identifying Molecular Regulators of Neuronal Functions Affected in the Movement Disorder Dystonia
Technical Report,01 Aug 2014,31 Jul 2015
University of Iowa Iowa City United States
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The movement disorder dystonia is characterized by involuntary muscle contractions in the limbs, hands, feet or neck. The aim of the research proposed here is to identify the functional changes that occur in brain neurons of a mouse model of DYT1 dystonia. The most significant finding during this period is that the intracellular Ca2 dynamics in the axons and dendrites of cultured brain neurons were abnormal in the model mice. This result indicates that the pathophysiology of dystonia can involve dysregulation of Ca2 -mediated events, such as synaptic transmission in the brain.